ICJIM

The Intercontinental Journal of Internal Medicine aims to publish issues related to all fields of internal medicine of the highest scientific and clinical value at an international level and accepts articles on these topics. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

EndNote Style
Index
Original Article
The impact of helicobacter pylori eradication on the oxidative stress index
Aims: Oxidative stress index is a parameter that is found by the ratio of total antioxidant status and total oxidant status. The oxidative stress index is a parameter that is found by the ratio of total antioxidant status and total oxidant status.
Methods: A total of 100 patients with H. pylori-positive and who were given eradication treatment were included in the study; a total of 46 men 29 of whom with H. pylori eradication and 17 without; a total of 54 women 28 of whom with eradication and 26 without.
Results: No significant difference in terms of oxidative stress index levels were found between the eradicated and non-eradicated groups. TAS levels were found to be 2,5± 0.4 in the non-eradicated group and 2.5 ± 0.3 in the eradicated group (p>0.05).
Conclusion: In our study, no significant difference was found in antioxidant and oxidative stress levels between H. pylori positive and negative groups after eradication treatment was given to the patients infected with H. pylori.


1. Kusters JG, van Vliet AH, Kuipers EJ. Pathogenesis of Helicobacterpylori infection. Clin Microbiol Rev. 2006;19(3):449-490. doi:10.1128/CMR.00054-05
2. Özden A. Helicobacter pylori 2006. GüncelGastroenteroloji. 2006;10(4):287-291.
3. Senchukova MA, Tomchuk O, Shurygina EI. Helicobacter pylori ingastric cancer: Features of infection and their correlations with long-term results of treatment. World J Gastroenterol. 2021;27(37):6290-6305. doi:10.3748/wjg.v27.i37.6290
4. Butcher LD, den Hartog G, Ernst PB, Crowe SE. Oxidative StressResulting From Helicobacter pylori Infection Contributes to GastricCarcinogenesis. Cell Mol Gastroenterol Hepatol. 2017;3(3):316-322.Published 2017 Feb 20. doi:10.1016/j.jcmgh.2017.02.002
5. Farinati F, Cardin R, Cassaro M, Bortolami M, Nitti D, Tieppo C, etal. Helicobacter pylori, inflammation, oxidative damage and gastriccancer: a morphological, biological and molecular pathway. Eur JCancer Prev. 2008;17(3):195-200.
6. Farinati F, Cardin R, Bortolami M, et al. OxidativeDNA damage in gastric cancer: CagA status and OGGI gene polymorphism. Int JCancer. 2008;123(l):51-55.
7. Ton AMM, Campagnaro BP, Alves GA, et al. Oxidative Stress andDementia in Alzheimer’s Patients: Effects of Synbiotic Supplementation.Oxid Med Cell Longev. 2020;2020:2638703. Published 2020 Jan 13.doi:10.1155/2020/2638703
8. Halliwell B, Gutteridge JMC. Free radicals in biology and medicine.Third ed. Oxford Science Publications. 2000: 617-624.
9. Young IS, Woodside JV. Antioxidants in health and disease. J ClinPatho l. 2001;54(3):176-186.
10. Gutteridge JMC. Lipid peroxidation and antioxidants as biomarkers oftissue damage. Clin Chem. 1995; 41: 1819-1928.
11. McCord JM. The evolution of free radicals and oxidative stress. Am JMed. 2000;108(8):652-9.
12. Farinati F, Cardin R, De Maria N, et al. Iron storage, lipid peroxidationand glutathione turnover in chronic anti-HCV positive hepatitis. JHepatol. 1995;22(4):449-456.
13. Higueras V, Raya A, Rodrigo JM, Serra MA, Romá J, Romero FJ et al.interferon decreases serum lipid peroxidation products of hepatitis Cpatients. Free RadicBiol Med. 1994; 16(1): 131-133.
14. Goode HF, Webster NR. Free radicals and antioxidants in sepsis. CritCare Med. 1993; 21(11): 1770-1776.
15. Feher J, Vereckei A, Lengyel G. Role of free-radical reactions in liverdiseases. Acta Physiol Hung. 1992; 80(1-4): 351-361.
16. Samuni A, Karmeli F, Moshen M and Rachmilewitz D. Mechanismsunderlying gastric anti ulcerative activity of nitroxides in rats. FreeRadic Res. 1999; 30(2):133-140.
17. Davies Cir, Banatvala N, Collins Ce, et al. Relationship between infectiveload of Helicobacter pylori and reactive oxygen metabolite production inantralmukosa. Scand J Gastroenterol. 1994;29(5):419-424.
18. Naito Y, Yoshikawa T. Molecular and cellular mechanisms involved inHelicobacter pylori-induced inflammation and oxidative stress. FreeRadicBiol Med. 2002; 33(3): 323-336.
19. Khanzode SS, Khanzode SD, Dakhale GN. Serum and plasmaconcentration of oxidant and antioxidants in patients of Helicobacterpylori gastritis and its correlation with gastric cancer. Cancer Lett.2003;195(1):27-31.
20. Aslan M, Nazligul Y, Horoz M, et al. Serum prolidase activity andoxidative status in Helicobacter pylori infection. Clin Biochem.2007;40(1-2):37-40.
21. Ernst P. Review article: the role of inflammation in the pathogenesis ofgastriccancer. Aliment Pharmacol Ther. 1999; 13 (Suppl 1): 13-18.
22. Lee KE, Khoi PN, Xia Y, et al. Helicobacter pylori and interleukin-8in gastric cancer. World J Gastroenterol. 2013;19(45):8192-8202.doi:10.3748/wjg.v19.i45.8192.
23. Rizzuti D, Ang M, Sokollik C, et al. Helicobacter pylori inhibitsdendritic cell maturation via interleukin-10-mediated activation ofthe signal transducer and activator of transcription 3 pathway. J InnateImmun. 2015;7(2):199-211. doi:10.1159/000368232
24. Bauditz J, Ortner M, Bierbaum M, Niedobitek G, Lochs H, Schreiber S.Production of IL-12 in gastritis relates to infection with Helicobacterpylori. Clin ExpImmunol. 1999;117(2):316-323.
25. Hida N, Shimoyama Jr T, Neville P, et al. Increased expression of IL-10and IL-12 (p40) mRNA in Helicobacter pylori infected gastric mucosa:relation to bacterial cag status and peptic ulceration. J ClinPathol.1999;52:658-664.
26. Meyer F, Wilson KT, James SP. Modulation of innate cytokine responsesby products of Helicobacter pylori. Infect Immun. 2000;68(11):6265-6272.
27. Tanahashi T, Kita M, Kodama T, et al. Cytokine expression andproduction by purified Helicobacter pylori urease in human gastricepithelial cells. Infect Immun 2000;68(2):664-671.
28. Farinati F, Della Libera G, Cardin R, et al. Gastric antioxidant,nitrites, and mucosal lipoperoxidation in chronic gastritis andHelicobacter pylori infection. J ClinGastroenterol 1996 ;22(4):275-281
29. Farinati F, Cardin R, Degan P, et al. Oxidative DNA damageaccumulation in gastric carcinogenesis. Gut 1998;42(3): 351-356.
30. Danese S, Cremonini F, Armuzzi A, et al. Helicobacter pylori CagA-positive strains effect oxygen free radicals generation by gastric mucosa.Scand J Gastroenterol. 2001;36(3): 247-250.
31. Choi J, Yoon SH, Kim JE, et al. Gene-specific oxidative DNA damagein Helicobacter pylori infected human gastric mucosa. Int J Cancer.2002;99(4): 485-490
32. Farinati F, Cardin R, Russo VM, et al. Differential effects of Helicobacterpylori eradication on oxidative DNA damage at the gastroesophagealjunction and at the gastric antrum. Cancer Epidemiol Biomarkers Prev.2004; 13 (11 Pt 1): 1722-1728.
33. Nishibayashi H, Kanayama S, Kiyohara T, et al. Helicobacterpylori-induced enlarged-fold gastritis is associated with increasedmutagenicity of gastric juice, increased oxidative DNA damage, and anincreased risk of gastric carcinoma. J GastroenterolHepatol. 2003;18:1384-1391.
34. Hahm KB, Lee KJ, Choi SY, et al. Possibility of chemoprevention bythe eradication of Helicobacter pylori: oxidative DNA damage andapoptosis in H. pylori infection. Am J Gastroenterol. 1997;92(10): 1853-1857.
35. Everett SM, White KL, Drake IM, et al. The effect of Helicobacterpylori infection on levels of DNA damage in gastric epithelial cells.Helicobacter. 2002;7(5):271-280.
36. Laderia MS, Rodrigues MA, Salvadori DM, Queiroz DM, Freire-MaiaDV. DNA damage in patients infected by Helicobacter pylori. CancerEpidemiol Biomarkers Prev. 2004;13(4): 631-637.
37. Laderia MS, Rodrigues MA, Freire-Maia DV, Salvadori DM. Use ofComet assay to assess DNA damage in patients infected by Helicobacterpylori: comparisons between visual and image analyses. Mutat Res.2005;586(1):76-86.
38. Arabski M, Klupinska G, Chojnacki J, et al. DNA damage and repairin Helicobacter pylori infected gastric mucosa cells. Mutat Res2005;570(1):129-135.
39. Shimizu T, Lee T, Shoji H, Kudo T, Satoh Y, Yamashiro Y. Urinary8-hydroxydeoxy-guanosine excretion in children before and aftertherapy for eradication of Helicobacter pylori infection. ActaPediatr.2003;92(9): 1026-1028.
40. Yoshida N, Sugimoto N, Ochiai J, et al. Role of elastase and activeoxygen species in gastric mucosal injury induced by aspirinadministration in Helicobacter pylori-infected Mongolian gerbils.Aliment PharmacolTher. 2002;16( Suppl 2):191-197.
41. Drake MJ, Davıes M, Mapstone PN, et al. Ascorbic acid may protectaganist human gastric cancer by scavening mucosal oxygen radicals.Carsinogenesis. 1996; 17(3):559-562.
42. Dinçer Y, Akçay T, Saygılı İE, Ersoy YE, Tortum O. Helicobacter pyloriile enfekte vakalarda Clarithromycin+Amoxicillin tedavisinin oksidatifDNA hasarı üzerine etkisi. International Journal OfHematology AndOncology. 2007;17(4):204-208.
43. Mc Cord JM. The superoxide free radical: its biochemistry andpathophysiology. Surgery. 1983; 94(3):412-414.
44. Başağa H. Proteinlerin radikaller tarafından inaktivasyonu veantioksidan maddelerin rolü. Biyokimya Dergisi. 1987; 3:25-33.
45. Naito Y, Yoshikawa T, Ando T, et al. Changes in superoxidedismutase activity in the gastric mucosa of peptic ulcer patients. JClinGastroenterol. 1992; 14 (Suppl 1): S131-134.
46. Yenice N, Aksoy N, Yücel M ve ark. SerbestoksijenradikalleriveHelicobacter pylori. Turk J Gastroenterol. 1996; 7 (suppl); B3.
47. Tanyalçın T. Özütemiz Ö, Kutay F ve ark. Helicobacter pylorigastritinde mide mukozası okside ve redükte glutatyon düzeyleri. TürkJ Gastroenterol. 1997; 8 (Suppl 1):63
48. Bahçecioglu İH, Yılmaz S, Üstündağ B, Doğukan A, Karaoğlu A,Dönder E. The mucosal levels of malondıaldehyde and glutathıonperoxıdase in the infection of Helicobacter pylori; effect of eradicatıon.T Klin J Gastroenterohepatol. 1998,9(2):65-69.
49. Suzuki H, Nishizawa T, Tsugawa H, Mogami S, Hibi T. Roles of oxidativestress in stomach disorders. J Clin Biochem Nutr. 2012;50(1):35-39.doi:10.3164/jcbn.11-115SR
50. Naito Y, Yoshikawa T. Molecular and cellular mechanisms involved inHelicobacter pylori-induced inflammation and oxidative stress. FreeRadicBiol Med. 2002;33(3):323-36.
51. Tandon R, Khanna HD, Dorababu M, Goel RK. Oxidative stress andantioxidants status in peptic ulcer and gastric carcinoma. Indian JPhysiolPharmacol. 2004;48(1):115-118.
52. Demiray M, Manavoğlu O. Helicobacter pylori vegastrikkarsinogenez.Uludağ Üniversitesi Tıp Fakültesi Derg. 29(2):29-33.
53. Koeppel M, Garcia-Alcalde F, Glowinski F, Schlaermann P, MeyerTF. Helicobacter pylori infection causes characteristic DNA damagepatterns in human cells. Cell Rep. 2015;11(11):1703-1713. doi:10.1016/j.celrep.2015.05.030
Volume 1, Issue 1, 2023
Page : 15-19
_Footer