ICJIM
Intercontinental Journal of Internal Medicine

The Intercontinental Journal of Internal Medicine aims to publish issues related to all fields of internal medicine of the highest scientific and clinical value at an international level and accepts articles on these topics. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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Non-diabetic hypoglycemia
Abstract
Glucose is the main substrate utilized by the brain, and therefore numerous counterregulatory mechanisms exist to maintain plasma glucose concentration. This makes it rare for hypoglycemia to develop in people who are not taking hypoglycemic drugs, such as insulin or sulfonylureas, for diabetes. The symptoms of hypoglycemia are nonspecific. The presence of Whipple’s triad is necessary for diagnosis. When symptoms occur spontaneously, the patient can be evaluated for hypoglycemia. If this is not possible, then a 72-hour fasting test or a mixed meal tolerance test can be performed to create conditions for symptoms to occur. Non-diabetic hypoglycemia is mainly divided into two main groups: insulin-mediated (hyperinsulinism) and insulin-independent. The main causes of hypoglycemia due to endogenous hyperinsulinism are insulinoma and islet cell hyperplasia (nesidioblastosis), post-bariatric surgery, and autoimmune hypoglycemia with the presence of anti-insulin antibodies. Other important causes of hypoglycemia include hypoglycemic drugs, non-islet cell tumors, hormonal deficiencies (primary adrenal insufficiency, anterior pituitary insufficiency), and critical illnesses (liver/kidney failure). In this article, we provide an overview of the pathogenesis and treatment of hypoglycemia.

Keywords : Hypoglycemia, non-diabetic hypoglycemia, insulinoma, nesidioblastosis, postprandial reactive hypoglycemia

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Article available in :
Volume 1, Issue 4, 2023
Page : 94-105
https://doi.org/10.51271/ICJIM-0021
Article Information
Received : 01 Eyl 2023
Accepted : 11 Eki 2023
Published : 29 Kas 2023
Corresponding Author :

Türkan Mete: Department of Endocrinology and Metabolism, VM Medical Park Samsun Hospital, Samsun, Turkey

[email protected]
Citation : Mete T, Cesur M. Non-diabetic hypoglycemia. Intercont J Int Med. 2023;1(4):94-105.

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