ICJIM
Intercontinental Journal of Internal Medicine

The Intercontinental Journal of Internal Medicine aims to publish issues related to all fields of internal medicine of the highest scientific and clinical value at an international level and accepts articles on these topics. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

eISSN: 2980-0846
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Online Manuscript System

Index
Case Report
An uncommon side effect: amiodarone-related hypothyroidism in a patient with negative thyroid autoantibodies.
Abstract
Amiodarone is an antiarrhythmic drug frequently used in cardiac dysrhythmias. One of the most important side effects of amiodarone is thyroid dysfunction. Amiodarone-induced thyrotoxicosis (AIT) and amiodarone-induced hypothyroidism (AIH) can occur depending on individuals' iodine status and previous thyroid disease. In this case, we aimed to present the hypothyroidism that developed in a patient with negative thyroid autoantibodies after amiodarone use.

Keywords : Amiodarone, levothyroxine, hypothyroidism

Download Article


1. Van Erven L, Schalij MJ. Amiodarone: an effective antiarrhythmicdrug with unusual side effects. Heart. 2010;96(19):1593-1600.doi:10.1136/hrt.2008.152652
2. Eskes SA, Wiersinga WM. Amiodarone and thyroid. Best Pract Res ClinEndocrinol Metab. 2009;23(6):735-751. doi:10.1016/j.beem.2009.07.001
3. Amador F, Mendonça F, da Costa C, et al. Total thyroidectomyin a patient awaiting heart transplant with amiodarone-inducedthyrotoxicosis: a case report. Clin Case Rep. 2023;11(2):e6892.doi:10.1002/ccr3.6892
4. Narayana SK, Woods DR, Boos CJ. Management of amiodarone-relatedthyroid problems. Ther Adv Endocrinol Metab. 2011;2(3):115-126.doi:10.1177/2042018811398516
5. Medic F, Bakula M, Alfirevic M, Bakula M, Mucic K, Maric N.Amiodarone and thyroid dysfunction. Acta Clin Croat. 2022;61(2):327-341. doi:10.20471/acc.2022.61.02.20
6. Florek JB, Lucas A, Girzadas D. Amiodarone. In: StatPearls. TreasureIsland (FL): StatPearls Publishing; 2023.
7. Eng PH, Cardona GR, Fang SL, et al. Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodidesymporter messenger ribonucleic acid and protein. Endocrinology.1999;140(8):3404-3410.
8. Ursella S, Testa A, Mazzone M, Gentiloni Silveri N. Amiodarone-induced thyroid dysfunction in clinical practice. Eur Rev MedPharmacol Sci. 2006;10(5):269-278.
9. Basaria S, Cooper DS. Amiodarone and the thyroid. Am J Med.2005;118(7):706-714. doi:10.1016/j.amjmed.2004.11.028
10. Trohman RG, Sharma PS, McAninch EA, Bianco AC. Amiodarone andthyroid physiology, pathophysiology, diagnosis and management. TrendsCardiovasc Med. 2019;29(5):285-295. doi:10.1016/j.tcm.2018.09.005
11. Trip MD, Wiersinga W, Plomp TA. Incidence, predictability,and pathogenesis of amiodarone-induced thyrotoxicosis andhypothyroidism. Am J Med. 1991;91(5):507-511.
12. Martino E, Aghini-Lombardi F, Mariotti S, et al. Amiodarone iodine-induced hypothyroidism: risk factors and follow-up in 28 cases. ClinEndocrinol. 1987;26(2):227-237.
Article available in :
Volume 1, Issue 4, 2023
Page : 109-110
https://doi.org/10.51271/ICJIM-0023
Article Information
Received : 27 Eki 2023
Accepted : 22 Kas 2023
Published : 29 Kas 2023
Corresponding Author :

Ali Can Memiş: Department of Internal Medicine, Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital, İstanbul, Turkey

[email protected]
Citation : Memiş AC, Temiz SG, Macunluoğlu Atakan BM. An uncommon side effect: amiodarone-related hypothyroidism in a patient with negative thyroid autoantibodies. Intercont J Int Med. 2023;1(4):109-110.

Read: 399
Cited: 0
Download : 200
_Footer