ICJIM
Intercontinental Journal of Internal Medicine

The Intercontinental Journal of Internal Medicine aims to publish issues related to all fields of internal medicine of the highest scientific and clinical value at an international level and accepts articles on these topics. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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Original Article
Isolated first hour hyperglycemia in oral glucose tolerance test is associated with insulin resistance
Abstract
Aims: To investigate metabolic and hemogram derived inflammatory markers in patients with isolated hyperglycemia on 1st hour of oral glucose tolerance test.
Methods: The subjects undergone 75 g OGTT for any reason were enrolled to the present retrospective cross sectional study. Plasma glucose, insulin and hemogram derived inflammatory markers, including mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) of the subjects in isolated hyperglycemia group compared to those in healthy controls.
Results: Mean PLR of the isolated hyperglycemia and control groups were 106.4±28.8% and 121.4±38%, respectively (p=0.043). Mean HOMA–IR values of patients and controls were 4.09±2.84 and 3.02±2.2, respectively (p=0.027). Plasma glucose at 1st hour was significantly correlated with fasting insulin (r=0.286; p=0.018) and HOMA-IR (r=0.32; p=0.007).
Conclusion: We think that isolated 1st hour hyperglycemia in OGTT should not be classified as normal since it is associated with increased fasting insulin and HOMA-IR levels. However, studies with larger cohort are needed to confirm our results

Keywords : Isolated hyperglycemia, oral glucose tolerance test, insulin, HOMA-IR, platelet to lymphocyte ratio

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Article available in :
Volume 2, Issue 1, 2024
Page : 1-6
https://doi.org/10.51271/ICJIM-0024
Article Information
Received : 01 Kas 2023
Accepted : 28 Kas 2023
Published : 29 Şub 2024
Corresponding Author :

Rıdvan Erdin: Department of Internal Medicine, Abant İzzet Baysal University Hospital, Bolu, Turkey

[email protected]
Citation : Erdin R, Güngüneş A, Erdin Z, Durmaz Ceylan Ş, Balcı SB, Aktaş G. Isolated first hour hyperglycemia in oral glucose tolerance test is associated with insulin resistance. Intercont J Int Med. 2024; 2(1):1-6.

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