ICJIM

The Intercontinental Journal of Internal Medicine aims to publish issues related to all fields of internal medicine of the highest scientific and clinical value at an international level and accepts articles on these topics. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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Review
Loss of appetite, weakness and chronic fatigue: current approach
Fatigue and chronic fatigue are frequently encountered complaints in clinical practice, and their etiology is difficult to determine. In addition to increasing patient dissatisfaction due to the lack of clarification of the etiology, it brings about a significant increase in cost due to the fact that patients consult multiple physicians. In this review, current clinical practices, including especially overlooked points in the etiology of weakness and fatigue, investigations that should be planned, diagnosis, treatment, and lifestyle recommendations, are reviewed.


1. Koutouratsas T, Kalli T, Karamanolis G, Gazouli M. Contribution of ghrelinto functional gastrointestinal disorders’ pathogenesis. World J Gastroenterol.2019;25(5):539-551.
2. Makris MC, Alexandrou A, Papatsoutsos EG, et al. Ghrelin andobesity: identifying gaps and dispelling myths. a reappraisal. In Vivo.2017;31(6):1047-1050.
3. Balasundaram P, Santhanam P. Eating Disorders. [Updated 2023 Jun 26].In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK567717/
4. Whiting P, Bagnall AM, Sowden AJ, Cornell JE, Mulrow CD, RamirezG. Interventions for the treatment and management of chronic fatiguesyndrome. A systematic review. Jama. 2001;286(11):1360-1368.
5. Terzi R, Altın F. Hastane çalışanlarında bel ağrısı sıklığı, bel ağrısınınkronik yorgunluk sendromu ve mesleki faktörler ile ilişkisi. Ağrı.2015;27(3):149-154.
6. Hawk C, Jason LA, Torres-Harding S. Differential diagnosis of chronicfatigue syndrome and major depressive disorder. Int J Behav Med.2006;13(3):244-251.
7. Goldenberg DL. Diagnosis and differential diagnosis of fibromyalgia.Am J Med. 2009;122(12):S14-S21.
8. Bates, DW, Buchwald D, Lee J, et al. Clinical laboratory test findings inpatients with chronic fatigue syndrome. Arch Int Med. 1995;155(1):97-103.
9. Zwarts MJ, Bleijenberg G, Van Engelen BGM. Clinical neurophysiologyof fatigue. Clin Neurophysiol. 2008;119(1):2-10.
10. Mills PJ, Kim JH, Bardwell W, Hong S, Dimsdale JE. Predictors offatigue in obstructive sleep apnea. Sleep Breath. 2008;12(4):397-399.
11. Kaçmaz Başoğlu Ö. Obstrüktif uyku apne sendromu klinik özelliklerive tanısı. Türkiye Klin J Pulm Med-Special Topics. 2017;10:7-13.
12. National Academy of Sciences. Beyond myalgic encephalomyelitis/chronic fatigue syndrome: redefining an illness. Mil Med.2015;180(7):721-723.
13. Hickie I, Bennett B, Lloyd A, Heath A, Martin N. Complex genetic andenvironmental relationships between psychological distress, fatigue andimmune functioning: a twin study. Psychol Med. 1999;29(2):269-277.
14. Myalgic encephalomyelitis: International Consensus Criteria. J Intern Med.2017;282(4):353.
15. DuBois RE, Seeley JK, Brus I, et al. Chronic mononucleosis syndrome.South Med J. 1984;77(11):1376-1382.
16. Jacobson SK, Daly JS, Thorne GM, McIntosh K. Chronic parvovirus B19infection resulting in chronic fatigue syndrome: case history and review.Clin Infect Dis. 1997;24(6):1048-1051.
17. Loebel M, Grabowski P, Heidecke H, et al. Antibodies to β adrenergicand muscarinic cholinergic receptors in patients with chronic fatiguesyndrome. Brain Behav Immun. 2016;52:32-39.
18. Clayton EW. Beyond myalgic encephalomyelitis/chronic fatigue syndrome:an IOM report on redefining an illness. JAMA. 2015;313(11):1101-1102.
19. 19. Lim EJ, Son CG. Review of case definitions for myalgic
20. encephalomyelitis/chronic fatigue syndrome (ME/CFS). J Translat Med.
21. 2020;18(1):289.
22. 20. Deumer US, Varesi A, Floris V, et al. Myalgic encephalomyelitis/chronic
23. fatigue syndrome (ME/CFS): an overview. J Clin Med. 2021;10(20):4786.
24. 21. Sapra A, Bhandari P. Chronic fatigue syndrome. [Updated 2023 Jun 21].
25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing;
26. 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/
27. NBK557676/
28. 22. Li SH, Sandler CX, Casson SM, et al. Randomised controlled trial of
29. online continuing education for health professionals to improve the
30. management of chronic fatigue syndrome: a study protocol. BMJ Open.
31. 2017;7(5):e014133.
32. 23. White PD, Goldsmith KA, Johnson AL, et al. Comparison of adaptive
33. pacing therapy, cognitive behaviour therapy, graded exercise therapy,
34. and specialist medical care for chronic fatigue syndrome (PACE): a
35. randomised trial. Lancet. 2011;377(9768):823-836.
Volume 2, Issue 1, 2024
Page : 17-20
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