ICJIM
Intercontinental Journal of Internal Medicine

The Intercontinental Journal of Internal Medicine aims to publish issues related to all fields of internal medicine of the highest scientific and clinical value at an international level and accepts articles on these topics. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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Original Article
Evaluation of the relationship between weight loss and oxidative stress in obese, type 2 diabetic patients by thiol/disulfide balance
Abstract
Aims: Diabetes mellitus (DM) and obesity continue to be an important problem in all world. It is known that there is a close relationship between DM and obesity and that both diseases have a course intertwined with inflammatory processes. In order to determine the clinical severity of these two diseases and to predict complications, clinical tools are needed to evaluate patients in terms of inflammation and oxidative stress. Anthropometric measurements and various known and novel inflammatory biomarkers are being tested for this purpose. Thiol/disulfide is a biomarker whose role in inflammatory processes and defense against oxidative stress is known and whose clinical value is still under investigation. In this study, we aimed to determine the relationship between body weight change and thiol/disulfide balance under clinical follow-up in obese patients with type 2 DM.
Methods: Our study was conducted in a single center with a prospective design between December 2023 and April 2024. The study was completed with a total of 46 patients. Age, comorbidities, height, body weight, waist and hip circumference measurements were performed; glycated hemoglobin, albumin, leukocyte, neutrophil and c-reactive protein values were recorded. After 3 months, the same data were obtained again. Blood samples obtained during these two examinations were analyzed for native thiol, total thiol, and disulfide.
Results: Of the 46 patients,30 patients lost more than %5 weight during the study period (Group 1) and the remaining 16 patients were defined as Group 2. There was no difference between Groups 1 and 2 in terms of age (p=0.211) and comorbidities (p=>0,05) at the beginning of the study. Inflammatory markers and thiol markers were similar between the groups at the beginning of the study (p=>0.05). Native thiol (263,20-316,51; p=0<0,001), total thiol (296,91-355,63; p=<0,001) and disulfide (9350,84-10845,39; p=0,024) were increased in group 1 cases during the study period. Disulfide/native thiol (6,41-6,19; p=0,199), disulfide/total thiol (5,67-5,50; p=0,207), native/total thiol (88,65-88,99; p=0,206) did not change. In group 2 cases, native thiol (272,81-289,59; p=0,135), total thiol (307,22-322,18; p=0,173), disulfide (3916,43-10609,44; p=0,059), disulfide/native thiol (6,51-6,23; p=0,178), disulfide/total thiol (5,75-5,54; p=0,2187), native/total thiol (88,49-89,92; p=0,188) did not change.
Conclusion: There were no differences between patients who lost and gained weight during the study period in terms of comorbidities, age and anthropometric measurements at the beginning of the study. There was a statistically significant change in thiol markers in patients who lost weight.

Keywords : Diabetes mellitus, obesity, inflammation, oxidative stress, thiol/disulfide balance

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Article available in :
Volume 2, Issue 4, 2024
Page : 99-105
https://doi.org/10.51271/ICJIM-0045
Article Information
Received : 18 Eyl 2024
Accepted : 28 Eki 2024
Published : 30 Eki 2024
Corresponding Author :

Betül Pekdoğan: Department of Internal Medicine, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkiye

[email protected]
Citation : Pekdoğan B, Varlıbaş A, Neşelioğlu S, Erel Ö, Çifci A. Evaluation of the relationship between weight loss and oxidative stress in obese, type 2 diabetic patients by thiol/disulfide balance. Intercont J Int Med. 2024;2(4):99-105.

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