Psoas abscess is a difficult disease to diagnose. MTB can cause psoas abscess. First generation anti-TB drugs are used in the treatment of TB, side effects may occur during treatment; one of these side effects is hypersensitivity reactions. In this case report, we aimed to present a patient who presented with recurrent psoas abscess occurs after pulmonary tuberculosis and developed hypersensitivity reaction to antituberculosis drugs and the treatment method we applied. A 44-year-old male patient presented with fever, cough and right flank pain. It was learned that he had hypothyroidism and received antibiotherapy and drainage treatment for recurrent psoas abscesses. His family history was unremarkable and respiratory sounds were normal. Fever was 37.8 °C. WBC: 6.640/mm³, CRP: 70mg/L, ESR: 33mm/h. Liver dynamic CT showed psoas abscess, drainage was provided.Pulmonary tuberculosis was thought to be the etiology of recurrent psoas abscess, thorax CT was ordered and culture and aside resitant staining (ARS) were sent from sputum and abscess upon observation of infiltrations.(Figure 1) No growth was observed in abscess culture and MTB was not detected. With the initiation of HRZE treatment, the patient developed sudden dyspnea, high fever, and skin rashes, and the treatment was terminated. Premedication was decided to be performed before the drug and progressive drug loading was performed to determine the responsible drug. The patient, who had no new allergic reaction during the treatment period, was discharged and methylprednisolone tablets were prescribed for 21 days, bilastine and desloratadine tablets were prescribed for 6 months together with TB drugs. Tuberculosis is among the important causes of morbidity and mortality in developing countries. At the beginning of treatment, patients should be told about the side effects that may occur with the drugs they use. In patients who develop hypersensitivity reactions, temporary or permanent discontinuation of drugs and often hospitalization of the patient is required. Antihistamines and steroids may need to be used for the control of severe reactions.In our case, we wanted to emphasize that patients may develop tuberculosis even if they do not present with pulmonary symptoms and that drug side effects should always be kept in mind and the necessity and importance of premedication and gradual drug loading therapy in patients with hypersensitivity reactions.