ICJIM
Intercontinental Journal of Internal Medicine

The Intercontinental Journal of Internal Medicine aims to publish issues related to all fields of internal medicine of the highest scientific and clinical value at an international level and accepts articles on these topics. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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Original Article
TSH receptor autoantibody levels in patients with non-toxic diffuse and nodular goiter
Abstract
Aims: To investigate TSH receptor antibody (TRAb) levels in patients with diffuse and nodular goiter and in patients which undergo thyroid operation.
Methods: 40 patients with non-toxic diffuse goiter (NTDG), 20 patients with non-toxic nodular goiter (NTNG), 20 patients undergo thyroid operation and 34 healthy subjects were involved. Thyroid function tests, TRAb levels were measured. All the patients were done thyroid sonography. In the opereation group, preoperative, postoperative 10th and 30th day TRAbs were studied.
Results: TRAb was significantly elevated in 20% of patients with NTNG, 30% of patients with NTDG and 35% of patients in the operation group (p>0.05). No TRAb(+) patient was found in the control group. TRAb levels in the postoperative period in the operated group were higher than in the preoperative period.
Conclusion: TRAb was found in euthyroid patients with goiter, different from the control group. In the group operated for goiter, postoperative TRAb levels were higher than preoperative levels. These findings indicated that autoimmunity may be involved in the development of non-toxic goiter.

Keywords : TSH receptor antibody, non-toxic, diffuse goiter, nodular goiter

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Article available in :
Volume 2, Issue 4, 2024
Page : 77-81
https://doi.org/10.51271/ICJIM-0041
Article Information
Received : 08 Eki 2024
Accepted : 20 Eki 2024
Published : 30 Eki 2024
Corresponding Author :

Zeynep Çetin: Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Amasya University, Amasya, Turkiye

[email protected]
Citation : Dortok Demir H, Çetin Z, Çelik C. TSH receptor autoantibody levels in patients with non-toxic diffuse and nodular goiter. Intercont J Int Med. 2024;2(4):77-81.

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