ICJIM
Intercontinental Journal of Internal Medicine

The Intercontinental Journal of Internal Medicine aims to publish issues related to all fields of internal medicine of the highest scientific and clinical value at an international level and accepts articles on these topics.

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Case Report
Vulvar and vaginal graft versus host disease in a patient with chronic phase chronic myeloid leukemia after allogeneic stem cell transplantation
Abstract
Graft versus Host Disease (GVHD) is one of the serious complications of allogeneic stem cell transplantation in the treatment of many hematological malignancies. Skin, liver, and eyes are frequently affected areas. In addition to frequently affected areas, genital region involvement can also be seen. Allogeneic stem cell transplantation is one of the definitive treatments for hematological malignancies seen in the young age group. And its use for therapeutic purposes in young patients is increasing daily. Vulvovaginal GVHD is a disease type that concerns female patients of reproductive age. In this case report, we wanted to report in the literature a case that underwent allogeneic stem cell transplantation after CML diagnosis and TKI resistance and then developed vulvovaginal GVHD. In vaginal disease involvement; in addition to many genitourinary complaints, many negativities in sexual life and deterioration in quality of life are experienced. The chronic GVHD patient we treated is currently continuing her treatment response follow-ups. Our aim in presenting this case to the literature is to emphasize that GVHD should be included in the differential diagnosis in female patients with hematological disease and vaginal involvement.

Keywords : GVHD, chronic myeloid leukemia, allogeneic stem cell transplantation

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Article available in :
Volume 3, Issue 1, 2025
Page : 19-21
https://doi.org/10.51271/ICJIM-0051
Article Information
Received : 06 Ara 2024
Accepted : 12 Oca 2025
Published : 07 Şub 2025
Corresponding Author :

Mehmet Orhan Ayyıldız: Department of Hematology, Faculty of Medicine, Dicle University, Diyarbakır, Turkiye

[email protected]
Citation : Ayyıldız O, Karakuş A, Pirinçci E, Gündüz R. Vulvar and vaginal graft versus host disease in a patient with chronic phase chronic myeloid leukemia after allogeneic stem cell transplantation. Intercont J Int Med. 2025;3(1):19-21.

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