ICJIM
Intercontinental Journal of Internal Medicine

The Intercontinental Journal of Internal Medicine aims to publish issues related to all fields of internal medicine of the highest scientific and clinical value at an international level and accepts articles on these topics.

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Original Article
Epstein-Barr virus RNA percentage and its impact on prognosis in patients with diffuse large B-cell lymphoma
Abstract
Aims: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphomas. This study aimed to investigate the impact of Epstein-Barr virus RNA (EBER) positivity on the prognosis of patients diagnosed with DLBCL.
Methods: This retrospective study was conducted on 105 patients diagnosed with DLBCL at Sivas Cumhuriyet University Hospital between June 1, 2009, and May 31, 2022.
Results: Of the 105 patients, 55.2% were male, and the mean age was 56.89 years. EBER positivity was detected in 4.8% of the patients. While 71% of EBER-negative patients achieved a complete response, overall survival and progression-free survival were shorter in EBER-positive patients. However, no significant relationship was observed between EBER positivity and prognostic indices (IPI, R-IPI, NCCN-IPI).
Conclusion: The findings of this study indicate that EBER positivity could act as a prognostic indicator, given its association with unfavorable survival rates and diminished response to treatment in individuals with DLBCL.

Keywords : Diffuse large B-cell lymphoma, EBER, prognosis

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Article available in :
Volume 3, Issue 1, 2025
Page : 15-18
https://doi.org/10.51271/ICJIM-0050
Article Information
Received : 29 Ara 2024
Accepted : 12 Oca 2025
Published : 07 Şub 2025
Corresponding Author :

Hatice Terzi: Department of Hematology, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkiye

[email protected]
Citation : Göçlü F, Terzi H, Yeldir N, Şencan M. Epstein-Barr virus RNA percentage and its impact on prognosis in patients with diffuse large B-cell lymphoma. Intercont J Int Med. 2025;3(1):15-18.

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