ICJIM
Intercontinental Journal of Internal Medicine

The Intercontinental Journal of Internal Medicine aims to publish issues related to all fields of internal medicine of the highest scientific and clinical value at an international level and accepts articles on these topics.

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Case Report
From hypothyroidism to Graves’ disease during pregnancy: a case of thyrotoxicosis following long-term hypothyroidism
Abstract
Graves’ disease is an autoimmune thyroid disorder characterized by hyperthyroidism, diffuse goiter, and orbitopathy, and it rarely occurs during pregnancy. A 23-year-old woman presented to the emergency department at 20 weeks of her second pregnancy with complaints of palpitations, sweating, and fatigue. She had previously been diagnosed with hypothyroidism by her family physician and had been on levothyroxine therapy. She had also been followed with hypothyroidism during her first pregnancy. Evaluation revealed findings consistent with thyrotoxicosis and positive thyroid autoantibodies, leading to a diagnosis of Graves’ disease. Propylthiouracil (PTU) therapy was initiated, and thyroid function was closely monitored throughout pregnancy. Both maternal and fetal outcomes were uneventful, and delivery occurred without complications. The development of Graves’ disease during pregnancy in a patient previously diagnosed with hypothyroidism is exceedingly rare. This case highlights the clinical importance of the transition from hypothyroidism to Graves’ hyperthyroidism during pregnancy.

Keywords : Graves disease, pregnancy, hyperthyroidism

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Article available in :
Volume 3, Issue 4, 2025
Page : 85-87
https://doi.org/10.51271/ICJIM-0065
Article Information
Received : 22 Eyl 2025
Accepted : 17 Eki 2025
Published : 26 Eki 2025
Corresponding Author :

Kübra Kaplan Kasar: Department of Family Medicine, Kırıkkale Provincial Health Directorate, Kırıkkale, Turkiye

[email protected]
Citation : Kaplan Kasar K, Kasar O. From hypothyroidism to Graves’ disease during pregnancy: a case of thyrotoxicosis following longterm hypothyroidism. Intercont J Int Med. 2025;3(4):85-87.

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